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Dr. Bob is Robert Hsiung, MD,
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Posted by geno on May 4, 2002, at 18:10:23
Hello, just wanted to ask this question. Today, my back was killing me, so i took 1/2 of a percocet. Im also on remeron/zoloft/desipramine and klonopin. At first if felt fine, but after a while, i became really MOODY, anxious, and my top of my head felt likeit was gonna expload. I did read that opiates do raise desipramine levels.
Iv used Vicodin in the past and felt great. Maybe my body cannot tolerate oxycodone???
geno
Posted by fairnymph on May 4, 2002, at 19:21:57
In reply to Opiates and med interactions, posted by geno on May 4, 2002, at 18:10:23
There is no significant interaction between those meds and opiates.
Posted by Elizabeth on May 7, 2002, at 0:16:47
In reply to Opiates and med interactions, posted by geno on May 4, 2002, at 18:10:23
Ever taken Percocet (or another oxycodone-containing medication) before? It might be that you can't tolerate it, for some reason. I've seen people get really dysphoric on oxycodone before.
On the other hand, it might well have been a drug interaction. It's hard to guess what might have been going on with the symptoms you described, but I'm guessing that you're right about the desipramine. The O-demethylation of oxycodone (to oxymorphone) is catalyzed by an enzyme that's crucial in the metabolism of tricyclic antidepressants, so it's conceivable that the oxycodone might have slowed the desipramine metabolism and clearance. I'm kind of impressed that such a tiny bit of oxycodone would have this effect, but then, you're taking a lot of meds, and one or more of the other ones may have contributed as well.
How much desipramine are you taking? Have you had your serum level checked?
-elizabeth
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