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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by christophrejmc on March 3, 2002, at 16:57:24
I'm thinking about switching from Nardil to selegiline (mostly due to some adverse effects from Nardil that I've never had from it before).
How fast can I make the switch? I'm on 75mg of Nardil right now (down from 90) and I'll be starting out on an MAO-B selective dose of selegiline. I've never had any withdrawl problems from ADs including the MAOIs, so I'll probably cold-turkey the Nardil. Should I wait the standard two weeks (yeah right, no way I'm waiting that long...)? What is a semi-safe, or even semi-risky waiting period? (My pdoc will most likely suggest going straight from one to the other but I'm not sure how safe that is.)
Thanks,
Christophre
Posted by Jason911 on March 4, 2002, at 12:32:42
In reply to Nardil to selegiline, posted by christophrejmc on March 3, 2002, at 16:57:24
I'd say you'd be fine if you waited a week after going cold turkey. Now, remember, if you want your depression helped (and I'm assuming you're quitting Nardil because of side-effects) you should take 5mg/day BUT ADD PHENYLALANINE daily to your regimen. That is the key. The PEA levels are what are going to help your depression (as well as a little more dopamine in the synapse). Phenylalanine is VERY cheap. GNC sells one bottle of 500mg (30 tabs) for $9.99. Start with a 5mg selegiline tab only, in the morning, for the first day. On the second day, take your 5mg tab in the morningand then one 500mg phenylalanine tab at noon and do this from this point on. You need to give that one day for the selegiline to work into your system. Always take the 5mg selegiline in the morning. You may have trouble getting to sleep at night. If you want to go the med route, I'd reccomend 2mg Klonopin before bedtime. Another option is a small dose of melatonin before bed. If that isn't enough, here is what I think is the best to take other than Klono to get to sleep. It's sold at GNC:
Preventive Nutrition® Sleep Formula
Product #703411
"This relaxing formula combines 90 mg of Kava Kava root extract, 2 mg of Melatonin, a natural hormone produced be the pineal gland that decreases with age. Also, enhanced with the desired levels of Griffonia seed extract, known as 5-HTP."Easy to swallow soft gels for faster absorption
Count: 60 soft gel capsules (2 months worth)
-Jason911 I'm confident your depression will be coming to an end! Let me know how it goes.
I'm thinking about switching from Nardil to selegiline (mostly due to some adverse effects from Nardil that I've never had from it before).
>
> How fast can I make the switch? I'm on 75mg of Nardil right now (down from 90) and I'll be starting out on an MAO-B selective dose of selegiline. I've never had any withdrawl problems from ADs including the MAOIs, so I'll probably cold-turkey the Nardil. Should I wait the standard two weeks (yeah right, no way I'm waiting that long...)? What is a semi-safe, or even semi-risky waiting period? (My pdoc will most likely suggest going straight from one to the other but I'm not sure how safe that is.)
>
> Thanks,
> Christophre
Posted by TSA West on March 6, 2002, at 21:26:50
In reply to Re: Nardil to selegiline » christophrejmc, posted by Jason911 on March 4, 2002, at 12:32:42
Reference for selegiline + phenylalanine:
"L-deprenyl plus L-phenylalanine in the treatment of depression." Journal of Neural Transmission. 59(1):81-7, 1984:
"The antidepressive efficacy of 1-deprenyl (5-10 mg daily) plus 1-phenylalanine (250 mg/day) has been evaluated in 155 unipolar depressed patients. Both oral and intravenous administration showed beneficial effects in 90% of outpatients and 80.5% of inpatients. It is concluded that this combined treatment has a potent antidepressive action based on the accumulation of 1-phenylethylamine in the brain."
This is the end of the thread.
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