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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by EricJ on July 30, 2001, at 14:37:31
Hey everyone -
I am prescribed for 2 tabs of 150mg Wellbutrin SR daily - I THINK I might have taken two pills Saturday morning instead of one (I couldn't remember if I had taken my pill that morning, so I took another one). Saturday I felt GREAT! my thinking was very clear, my mood and attitude was very good, etc.
I'm curious if anyone is prescribed for more than 300 mg Wellbutrin daily. I'm thinking maybe I need to up my dosage... for the past two weeks, my suicidal thoughts have come back (although not as bad as pre-Wellbutrin) and I'm having some mildly obsessive thoughts.
Looking at Wellbutrin website, it appears that the risk of seizure increases with an increase in dosage - I'm wondering how commonly pdocs might prescribe a dosage more than 300 mg/daily.
thanks for sharing your dosage info with me.
Eric
Posted by paxvox on July 30, 2001, at 19:48:51
In reply to Anyone on more than 2x150mg Wellbutrin SR daily?, posted by EricJ on July 30, 2001, at 14:37:31
Eric, I have had up to 300 mg x 2, which caused too much chest pain. Dropped back to 200 mg x 2, too much chest pain. Back to original dose of 150 SR x 2. Am doing OK at that dose. As I have said in my other postings, each person reacts differently to meds, and individual dosing is a must for active DOC/patient participation.
Posted by SalArmy4me on July 30, 2001, at 21:23:08
In reply to Anyone on more than 2x150mg Wellbutrin SR daily?, posted by EricJ on July 30, 2001, at 14:37:31
I think that the risk of seizures associated with Wellbutrin is exaggerated. In the early studies, the rate of occurence was about 0.30 percent in general patient populations at dosages as high as 900mg. This is about equal to the tricyclics. More recent studies indicate that the SR (sustained release) version of Wellbutrin at dosages up to 300mg carries no greater risk to produce seizures than most other antidepressants; the rate being about 0.10 percent. However, the rate of seizure increases significantly in people with a pre-existing seizure disorder. It is also increased when treating people who have an imbalance of electrolytes such is seen in eating disorders like bulemia. The rate of seizure also increases at dosages greater than 300mg. Even so, the rate at 450mg is no greater than that of the tricyclics. I would not want to speculate at dosages exceeding 450mg. More frequent dosing helps to minimize risk. It was during a pre-marketing investigation designed to study the efficacy of Wellbutrin in treating bulimia that seizures emerged. I think most of the bad reputation this drug has was born of that study.
Posted by terra miller on July 30, 2001, at 23:26:56
In reply to Anyone on more than 2x150mg Wellbutrin SR daily?, posted by EricJ on July 30, 2001, at 14:37:31
Eric,What Sal. said.
I totally agree.
-terra
This is the end of the thread.
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