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Dr. Bob is Robert Hsiung, MD,
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Posted by AndrewB on May 20, 2000, at 10:47:01
Inositol is a possible remedy for medication poop out. The excerpt below is from the book 'Betrayal by the Brain' by Dr. Jay Goldstein
Drug Tolerance-
large doses of inositol (inositol poorly penetrates the blood-brain barrier) affects the sensitization of the alpha-1 receptor and can sometimes reverse tolerance to a previously helpful medication.Case Report
16 yr old, home bound for 2 years with CFS, too cognitively impaired toreceive home tutoring. She initially had excellent response to Zantac, naphazoline, nimodepine, oxytocin, and several antidepressants, but thebenefit was always short-lived. After taking one gram of inositol she felt considerably better and was encouraged to resume agents to which shehad developed tolerance. As long as she continued to take inositol 1 gmqid, these medications were again effective. She has returned to high school and will be graduating shortly.
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